Intralesional Treatment With 5-Fluorouracil and Steroid Improves Allergic Contact Dermatitis Without Causing Skin Atrophy and Rebound Lesions

To the Editor: Intralesional triamcinolone acetonide (TA) injections can rapidly and effectively treat severe localized dermatitis. However, these treatments are associated with adverse effects such as dermal atrophy, hypopigmentation, capillary dilation, and Cushing syndrome. These adverse effects may be attributable, in part, to the large doses of TA required to obtain the desired outcome. The combination of 5-fluorouracil (5-FU) and TA has been shown to be superior to TA monotherapy in patients with keloids and hypertrophic scars. Furthermore, combination therapy reduces the required dosage of both drugs. However, limited data are available on the use of intralesional TA injections along with 5-FU for the treatment of allergic contact dermatitis (ACD).